Simultaneously, the stability of HDAC6 is modulated by Hsp90 [33], while the degradation of HDAC6 is regulated by cullin 3SPOP ubiquitin E3 ligase that has been shown to promote HDAC6 polyubiquitination and degradation in proteasomes in multiple cancer cell lines, including CRC [86]. Here, HDAC6 is linked to colorectal carcinoma.