TP53 and cancer: Recently, it has been reported that the transcription of the PD-1 gene in cancer cells is regulated via acetylation of the p53 tumor suppressor by HATs p300, CBP, and Tip60 in a manner that acetylated p53 recruits the acetyltransferase cofactors to interact with the PD-1 promotor and induce the expression of PD-1 [240].