Regarding NK cell antitumor activity, it was reported that the pan-HDACis vorinostat and trichostatin A induced the expression of MHC class I-related chain A (MICA) and B ligands to activate the NK cell receptor NKG2D in hepatocellular carcinoma and Ewing sarcoma and thereby increased the susceptibility of treated tumor cells to NK cell-mediated lysis [209,219]. This evidence concerns the gene KLRD1 and neoplasm.