CASP9 and colonic neoplasm: These experimental results are confirmed by previous literature reports; Ardestani et al. revealed that Lactobacillus brevis inhibited the growth of HT-29 colon cancer cells and induced apoptosis by increasing the expression of BAX, caspase-3, and caspase-9 mRNA levels, while reducing the expression of Bcl-2 protein levels [41].