CASP3 and breast carcinoma: Indeed, LP extract was previously reported to decrease the level of the anti-apoptotic Bcl-2 protein and increase the apoptotic BAX protein, simultaneously activating caspase-3 and -9 [28], thus qualifying as an intrinsic apoptosis inducer; similarly, Senturk et al. revealed the downregulation of Bcl-2 in MCF-7 breast cancer cells by LP secondary metabolites [42].