0.8% IFD-attributable mortality during RIC (only one death related to IPA);Median OS of 689 days in PSZ group vs. 514 days in no AFP group, causes of death were superimposable, with leukaemia as the leading cause;First induction chemotherapy failure (HR 4.48);PSZ discontinuation rate of 34% (half of cases due to liver toxicity);No significant difference in proven/probable IPA incidence or OS between groups (PSZ vs. no AFP). This evidence concerns the gene AFP and toxicity.