CD8A and Alzheimer disease: Subsequently, CD8 effector memory CD45RA+ (TEMRA) cells have been found to be responsible for proinflammatory and cytotoxic functions in AD patients and to play an important role in disease progression; two antigens of EBV (the Epstein–Barr nuclear antigen 3 and the trans-activator protein BZLF1) have been identified as stimulators of this adaptive immunity in AD patients [80,81].