Bioinformatic analysis of the differentially regulated protein in NSC + PR8 and CLIC1 KD + PR8 cells by Ingenuity Pathway Analysis (IPA) revealed that activation of cells, cell movement, migration of cells, cell cycle progression, and viral infection were activated/increased by PR8 infection in wild-type cells but inhibited/decreased in CLIC1 KD cells. The gene discussed is CLIC1; the disease is viral infectious disease.