For example, nascent polypeptide-associated complex subunit alpha (NACA), insulin-like growth factor-binding protein 6 (IGFBP6), peptidylprolyl isomerase F (PPIF), EPH receptor A3 (EPHA3), and interleukin 11 (IL11) were significantly up-regulated, and the expression of histone acetyltransferase 1 (HAT1), H2A.Z variant histone 1 (H2AZ1), peptidylprolyl isomerase D (PPID), calcium/calmodulin-dependent protein kinase II beta (CAMK2B), and aryl hydrocarbon receptor-interacting protein (API) were down-regulated but were not significantly affected in CLIC1 KD cells after PR8 infection. The gene discussed is H2AZ1; the disease is infection.