Interestingly, the KO of IFN-β, specifically in neurons, oligodendrocytes, and astrocytes, did not increase viral replication, CNS inflammation, or hippocampal sclerosis, suggesting a role for microglia in infiltrating immune cells on an IFN-β-driven antiviral immune response and the resistance to TMEV persistence and demyelinating disease in BL6 mice [45]. This evidence concerns the gene IFNB1 and demyelinating disease.