For example, KAP1 is recruited to the Primer Binding Site (PBS) of the integrated murine leukemia virus by a KRAB-domain-containing ZFP protein [60] through HP1 recruitment via the HP1 box [61] and SUMOylation of specific residues within the BD [62] to promote transcriptional silencing in embryonic stem and carcinoma cells. This evidence concerns the gene TRIM28 and carcinoma.