HIF1A and neoplasm: Induced expression of miR-143 in cervical cancer cells resulted into increased apoptosis as well as improved reaction to Cisplatin treatment, data that renders miR-143 a possible tumor-suppressing microRNA, as well as a candidate biomarker for prognosis or the optimization of cervical cancer treatment [27,44] Zhao et al. demonstrated, using dual-luciferase reporter gene assay, that miR-143 directly targets and silences HIF-1a by binding on its 3′UTR, thus, negating the transcription factor’s effects in the cervical tumor microenvironment and ameliorating the cancerous phenotype.