Considering IRF7’s role as both a DEG in AD and SARS-CoV-2 infection and also as a transcription factor that might bind with the human ACE2 promoter, which is very important for viral penetration into cells [87], we suspected that IRF7 might be a key factor for SARS-CoV-2 infection and AD progression. Here, ACE2 is linked to Alzheimer disease.