CCL5 and Zika virus infectious disease: Blocking the interaction of CCL5 with CCR5 on ZIKV-infected hBMECs knocked-out for either CCR5 or CCL5 resulted in a significant decrease in ZIKV infection (Figure 4) and a reduction in the cell viability of the hBMECs, suggesting that the CCR5:CCL5 interaction promotes the survival of the ZIKV-infected brain endothelium, allowing for persistent infection.