Liver fibrosis, characterized by the massive accretion of extracellular matrix proteins (ECM) including collagens I/III, laminin, and alpha smooth muscle actin (α-SMA) in the liver, is associated with persistent hepatocellular damage due to viral infection (e.g., hepatitis B and C) and fatty liver [1,2]. Here, ACTA1 is linked to Hepatic fibrosis.