In renal tubular epithelial cells (NRK-52E) and hyperuricemia mice, UA induced the infiltration of inflammatory cells in the tubulointerstitium, up-regulated the production of inflammatory cytokine TNF-α, and regulated the expression of activated normal T cells and secreted factors through the NF-κB signaling pathway [30]. Here, NFKB1 is linked to hyperuricemia.