KEGG analysis enriched the top 35 signaling pathways, including lipid and atherosclerosis, TNF signaling pathway, AGE-RAGE signaling pathway in diabetes complications, NOD-like receptor signaling pathway, apoptosis, NF-κB signaling pathway, IL-17 signaling pathway, p53 signaling pathway and other potential pathways related to HUA (Figure 6B). This evidence concerns the gene TNF and diabetes mellitus.