The rs738409 variant (I148M) of the Patatin-like phosphatase domain-containing 3 (PNPLA3) gene is the most common gene associated with non-alcoholic fatty liver disease (NAFLD) [1,2], a condition contributed by genetic factors in one-third of individuals [3]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.