Regarding the role of bergamot derivatives and byproducts on metabolic disorders, it was seen that a bergamot leaf extract (BLE) is able to decrease inflammation (TNF-α and IL-6 levels) and oxidative stress, acting on the adipose tissue–liver axis of obese rats, with an effect which might improve both insulin resistance and dyslipidemia conditions [85]. This evidence concerns the gene TNF and Insulin resistance.