Additionally, a KEGG pathway analysis unveiled substantial changes in peroxisome proliferator-activated receptor (PPAR) signaling, fatty acid metabolism, the biosynthesis of cofactors, ribosomes, Huntington’s disease, and autophagy pathway-related genes in the curcumin-supplemented HFHSD group (Figure 2D). The gene discussed is PPARA; the disease is juvenile Huntington disease.