IL6 and Anorexia: The systemic inflammation is also associated with the increase of pro-inflammatory cytokines, such as tumor-necrosis factor-α (TNF- α), interleukin- 1(IL1), interleukin-6 (IL6), and interferon-γ (IFN-γ) in the hypothalamus, promoting the inactivation of orexigenic neurons which are responsible for anorexia [9,28].