A recent report has shown that oral administration of amorphophallus konjac extracts containing glucosylceramide, which is primarily composed of ceramide with 4,8-sphingadienine and 2-hydroxystearic acid (d18:2/18h:0), for 14 days reduces Aβ pathology and synaptic toxicity in the brains of APP transgenic mice, as well as improving memory impairment [37]. This evidence concerns the gene APP and memory impairment.