We subsequently discovered that JAK/STAT3, PI3K/AKT, and MEK/ERK-1/-2 pathways were involved in IL-6-induced clonogenicity and invasiveness of SW480, and the neutralization of IL-6R could reverse the IL-6 effect on signaling transduction, suggesting the potential therapeutic role of the anti-human IL-6R antibodies in CRC cell progression [15]. This evidence concerns the gene MAPK3 and colorectal carcinoma.