GPR85 and schizophrenia: Out of the expressions of GPRs that were found to be associated with schizophrenia as risk factors, GPR-85 expression seems to play a role in delaying the development of the brain, as it has been found that Tg mice carrying the GPR-85 gene have lower brain volumes and cytoarchitecture disturbances in the cortex while the KO mice had increased brain volumes and neurogenesis in the hippocampus.