GPR-52 expression is colocalized with D1 receptors in the cortex and D2 receptors in the striatum, and it is proven to be mainly associated with glutamatergic cells in the PFC [13], which are known to have reductions in dendrite arborization, spine density, and synaptophysin expression across frontal and temporal regions in schizophrenia [27]. Here, GPR52 is linked to schizophrenia.