The role of GPR-88 expression in the pathophysiology of schizophrenia is also supported by the fact that its expression influences cognitive and motor functions, as demonstrated by the silencing of the GPR-88 gene in the nucleus accumbens, which reduces the typical manifestations of schizophrenia induced by amphetamine administration in the PCP-induced schizophrenia model in mice [23]. This evidence concerns the gene GPR88 and schizophrenia.