The activation of nuclear factor erythroid-derived 2-like 2 (NRF2) has also been demonstrated as a protective mechanism of LPZ against non-alcoholic steatohepatitis in model rats induced by a choline-deficient amino-acid-defined diet [28] and acute liver damage in a rat model induced by thioacetamide [29]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.