Inhibition of MSU-induced paw swelling and joint inflammation in the footpad gout model. Decrease of neutrophil infiltration, secretion of IL-1β, IL-6 and MCP-1, and NLRP3 expression in mice with MSU-induced peritonitis.Improvement of renal dysfunction and lowering of serum urate, blood urea nitrogen and creatinine levels in the hyperuricemic mouse model. The gene discussed is NLRP3; the disease is peritonitis.