TNF and colorectal carcinoma: KEGG enrichment analysis (Figure 1E) revealed that the key targets of ISL that antagonise CRC were mainly concentrated in the oestrogen signalling pathway, TNF (tumour-necrosis-factor) signalling pathway, PI3K/AKT (phosphatidylinositol-3-kinase/protein kinase) signalling pathway and other classical signalling pathways.