Mitochondrial proteins containing hydroxysteroid 17-beta dehydrogenase 10 (HSD17B10), alanyl-tRNA synthetase 2 (AARS2), translocase of outer mitochondrial membrane 40 (TOMM40), Cyt C oxidase subunit 5A (COX5A), voltage-dependent anion channel 1 (VDAC1), and renamed COXFA4 (NDUFA4) are associated with AD-related mitochondrial dysfunction. This evidence concerns the gene COXFA4 and Alzheimer disease.