Nanotechnology improves the characteristics of curcumin and endows it with the ability to target an infected area, as well as inhibit viral replications that prevent the TMPRSS2 from interacting with disintegrin metallopeptidase domain 17 (ADAM17) to give a high level of ACE2 expression, causing lung inflammation and pulmonary oedema [109]. Here, TMPRSS2 is linked to pulmonary edema.