Studies on seizure models such as those of traumatic brain injuries (TBIs) and pilocarpine–lithium rat models have demonstrated that perampanel may reduce apoptosis and decrease the synthesis of cytokines such as TNF-α, IL-1ß, IL-6, and IL-10 as well as inducible nitric oxide synthetase (iNOS) and neuronal NOS (nNOS) [14,15]. This evidence concerns the gene NOS1 and Seizure.