Additional causes of graft vasculopathy include obesity, coronary artery disease, dyslipidemia, diabetes, donor age, male gender, brain-dead donors, increased graft ischemia time [79], hypercholesterolemia [80], increased end-diastolic diameter and decreased interleukin 33 (IL-33), as well as the increased suppression of tumorigenicity 2 (ST2) [81]. The gene discussed is IL33; the disease is obesity due to melanocortin 4 receptor deficiency.