MACROH2A1 and fatty liver disease: Nevertheless, an increased liver content of core histone macro-H2A.1 has been identified in murine models of hepatic steatosis [41] and fat-associated hepatocellular carcinoma [42], and an upregulation of immunoglobulin lambda variable 3-19 has been shown in the serum samples of 16 patients with autoimmune cirrhosis compared to the healthy control group [43].