Mortality risk was higher in overhydrated patients (OR: 6.2, 95% CI: 1.2–32.6, p = 0.02) and in persistently overhydrated patients (OR: 9.57, 95% CI: 1.18–77.5, p = 0.03) even after adjustment to age, serum albumin and acute kidney injury (AKI) in stages 2–3. The gene discussed is ALB; the disease is acute kidney injury.