TARDBP and Alzheimer disease: In the 21st century the relevance of previously not well-known brain pathologies (vascular, LBD, TDP-43 (mainly LATE), hippocampal sclerosis, argyrophilic grains), associated with the hallmarks of AD pathology and with other biologic features of aging is notorious (Section 3.2.6) [367,395,420,451,484,485,486].