MAPT and Alzheimer disease: We must stress that we do not know the initial trigger of brain lesions in AD: amyloid derangement and a secondary tau disorder according to ACH [368,369,503], tau according to histology [63,222,223], or others (neuron disruption by calcium, autoimmunity, infectious, parainfectious or other neuroinflammation, neural senescence, etc. [316,317,318,319,496,497,508]).