The characteristics of T2 asthma are an increased secretion of IL-4, IL-5, and IL-13 through Th2 and innate lymphoid cells type 2 (ILC2), increased IgE reactivity, elevated blood eosinophils and a fraction of exhaled nitric oxide (FeNO), a good response to inhaled corticosteroids (ICS), and biologics [14,17]. This evidence concerns the gene IGHE and asthma.