NPPA and hypertensive disorder: The cardiac NPs system (ANP and BNP), due to its diuretic, natriuretic, vasorelaxant, cardiac and vascular antifibrotic and antihypertrophic effects, RAAS and sympathetic nervous system inhibition, as well as anti-atherosclerotic properties, appears to be a key candidate among potential biomarkers involved in the pathogenesis of HTN and HHD (Table 1) [56,57,58].