Despite some limitations, an interesting finding shown by Wang et al. in a prospective, large and well-defined cohort of normotensive individuals investigating the association of nine biomarkers (CRP, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), aldosterone, renin, BNP, NT-proBNP, homocysteine and urinary albumin/creatinine ratio (UACR)) with the development of HTN was that the three best-performing biomarkers were CRP, PAI-1 and UACR [94]. The gene discussed is SERPINE1; the disease is hypertensive disorder.