AGT and hypertensive disorder: High blood pressure leads to an elevation in the levels of angiotensin II, catecholamines, and the parathyroid hormone (PTH) [43], and the sustained elevation of PTH increases osteoclast formation and differentiation by upregulating the receptor activator of nuclear factor-κβ ligand (RANKL), which plays a critical role in adequate bone metabolism [44], which may contribute to bone resorption.