TNFRSF11A and hypertensive disorder: More directly related to the dental field, the results of an animal study show that hypertension can alter the expression of receptor activator of nuclear factor-κβ (RANK), RANKL, and osteoprotegerin (OPG, which plays a role in the regulation of bone density), and delay the socket-bone-healing process after tooth extraction., which can exert an influence on some dental procedures, such as implant placement [49].