In line with this, Kang et al. demonstrated that patients with higher NT-proBNP levels had an increased risk of all-cause mortality and rehospitalization for worsening HF after 1 year, irrespective of the presence of HFrEF and HFpEF, including 1670 patients enrolled in the Korean Heart Failure registry [39]. This evidence concerns the gene NPPB and hydrops fetalis.