Of note, the diagnosis of ADHF may be improved when incorporating baseline characteristics, clinical characteristics, and the measurement of eGFR and hemoglobin in addition to the measurement of NT-proBNP—this approach, the so-called CoDE-HF decision support tool, was recently introduced, including 10,369 patients with suspected ADHF, and revealed an AUC of 0.846 in patients with previous HF and of 0.925 in patients without prior HF, respectively [14]. The gene discussed is NPPB; the disease is hydrops fetalis.