Since there is large individual variability in insulin requirements, which can be augmented by several factors such as meals, physical activity, stress, hormonal impairment inflammation, and infections, along with variable individual responses to insulin action, T1DM patients tend to have higher glycemic fluctuations with an increased risk of developing hypoglycemic and hyperglycemic episodes and accentuating glycemic instability, making it necessary to develop new indicators for quantifying glycemic oscillations [8,9,10]. The gene discussed is INS; the disease is type 1 diabetes mellitus.