Table 1 shows the baseline characteristics in the analysis of MACCEs. Within the entire cohort, the SGLT-2 inhibitor group showed a higher incidence of hyperlipidemia, hypertensive disorder, heart failure, ischemic or coronary heart disease, and peripheral vascular disease. We found no significant differences in the baseline variables of the PS-matched population between groups (Supplementary Figure S1); in terms of pneumonia diagnosis, a total of 12,400 matched pairs were generated, and showed no difference after propensity matching (Table 2, Supplementary Figures S2 and S3). The gene discussed is SLC5A2; the disease is heart failure.