In a 2015 study by Bagnato et al. on a total of 105 female patients (70 SSc and 35 HT), anti-TPO and anti-Tg antibodies were found to be positive in more control patients with HT (62% and 51%, respectively) when compared to SSc patients both dcSSc and lcSSc (11% and 24%, respectively), with the difference being statistically significant. Here, TPO is linked to systemic sclerosis.