No significant differences were found in the prevalence of calcinosis, digital ulcers, gastrointestinal involvement, ILD, primary heart involvement, PAH on echocardiography, kidney involvement, SRC, joint involvement, overlap syndromes, myalgia, myositis, anti-Scl-70 antibodies, anti-Pm/Scl, ARAs, anti Tj1/Th0, anti-Ku, anti-Nor 90 or ACAs between SSc patients with or without anti-thyroid antibodies. This evidence concerns the gene PRB1 and overlapping connective tissue disease.