The study included a retrospective cohort of 130 patients with pituitary adenomas, and the patients were classified according to seven hormone secretion profiles, including non-functioning pituitary adenomas (NFPAs), GH-secreting adenomas, prolactinomas, ACTH-secreting adenomas, FSH/LH-secreting adenomas, TSH-secreting adenomas, and pluri-hormonal secreting adenomas. This evidence concerns the gene PLOD1 and adenoma.