Moreover, three innovative strategies are described for the treatment of migraine: one linked to the role of the CGRP, another linked to nutritional strategies and innovative diet therapy protocols such as the ketogenic diet, and transcutaneous electrical nerve stimulation (TENS) therapy, which is a fast-acting, effective therapy for the treatment of acute migraine that is used in emergency departments [40,41]. The gene discussed is CALCA; the disease is migraine disorder.