In general, HF is unlikely at BNP values < 100 pg/mL and is very likely at BNP values > 500 pg/mL and, similarly, unlikely at NT-proBNP values < 300 pg/mL and very likely at NT-proBNP values > 450 pg/mL (>900 pg/mL in patients over 50 years of age) [56]. Here, NPPB is linked to hydrops fetalis.