GHSR and retinal disorder: In this regard, preclinical studies have evidenced antioxidant and neuroprotective actions on the retinal layers exerted by ghrelin in a rat model of glaucoma [52], as well as its modulation of retinal angiogenesis through GHSR-1a in a rat model of oxygen-induced retinopathy (OIR), where ghrelin seems to have therapeutic potential for proliferative retinopathies [51].