This could be partially explained by the fact that women experience more symptoms and signs of HF than men; yet, one would expect that the greater symptom burden would be accompanied by worse physiological markers of HF severity (EF, N-terminal pro-brain natriuretic peptide (NT-proBNP), prior HF hospitalization), which is, however, not the case [57]. Here, NPPB is linked to hydrops fetalis.