The development of DCM is linked to over 110 genes, including sarcomere genes (MYH7, TPM1, and TTN), calcium-sensitive and calcium-signaling genes (JPH2, and PLN), z-disk genes (ACTN2, BAG3, and CRYAB), and nuclear envelope genes (LMNA, EMD) [91]. This evidence concerns the gene PLN and familial dilated cardiomyopathy.