Our prospective, single-center cohort study aimed to assess the prevalence of germline DDR gene mutations (BRCA1, BRCA2, ATM, CHEK2, and NBN) in patients with localized PCa that was diagnosed based on positive findings of multiparametric magnetic resonance and ultrasound imaging (mpMRI/UG) fusion-guided targeted biopsy. Here, DDR1 is linked to posterior cortical atrophy.