The DDR gene mutations rate was also high in the cISUP > 1-grade group scores among advanced PCa cases [19] and exceeded mutation prevalence in the localized cISUP > 1 disease (59.10% vs. 33.33%, p = 0.13), and the number of cISUP > 1-grade group patients with CHEK2 mutation was markedly higher in mCRPC as compared to localized PCa: 66.67% vs. 23.08% (p = 0.047) (Figure 3). Here, CHEK2 is linked to posterior cortical atrophy.