Since DDR deficiency may be associated with an aggressive cancer phenotype, knowledge of DDR gene status in localized stage disease may be critical, requiring more accurate decision-making in various clinical settings, such as choosing active surveillance over radical therapy or surgery over radiation, assessing the optimal timing of salvage radiotherapy after radical prostatectomy, and many other. Here, DDR1 is linked to hyperinsulinemic hypoglycemia, familial, 4.