INS and polycystic ovary syndrome: Briefly, Sprague-Dawley rats, upon exhibiting a vaginal plug indicative of GD 0.5, were administered daily doses of DHT (1.66 mg/kg) and insulin (6.0 IU) from GD 7.5 to 13.5 to induce a state of PCOS-like hyperandrogenism and insulin resistance [111].