CHCHD2 and neurodegenerative disease: In human cells, MIA substrates have been linked to neurodegenerative diseases such as CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10) in amyotrophic lateral sclerosis [22] and CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2) in Parkinson’s Disease [23].