GMFB and Parkinson disease: If the degeneration of DA neurons in SN was associated with GMF up-regulation in PDD, it would suggest that the inhibition of GMF expression through anti-inflammatory therapy such as GMF-specific monoclonal antibodies or GMF gene silencing approaches including small interfering RNA (siRNA), short hairpin RNA (shRNA), and CRISPR/Cas9 based GMF gene editing for PD patients might have beneficial effects by halting the neurodegenerative process or inhibiting neuroinflammatory mechanisms.