HYAL1 and breast carcinoma: Thus, whereas Varallo et al. [37] have described a higher expression of HYAL-1 in canine mammary carcinoma when compared with healthy tissue, Sakalauskaite et al. [9] observed no difference between carcinoma and healthy adjacent tissue, except in German Sheperd bitches, which showed a higher expression of HYAL-1 in the adjacent tissue.