An example regarding the use of this type of skin-on-a-chip model was recently reported by Kim et al. [78] in an article where the potential therapeutic ability of the microbial metabolite I3LA was tested on a skin-on-a-chip AD model, where the skin disease was recreated exploiting two AD-inducing factors, IL-4 and IL-13. This evidence concerns the gene IL4 and Alzheimer disease.