The Phenion® Full Thickness Skin Model was selected for a very interesting and recent study by Rohrbeck et al. [50], where a psoriasis-like phenotype was induced by the addition of cytokines to test the healing effect of Clostridium botulinum C3 exoenzyme (C3bot): it was found that C3bot administration caused a reduction in the cytokine-induced psoriasis-like phenotype inhibiting the cytokine-induced expression of IL-6. This evidence concerns the gene IL6 and psoriasis.