Dysfunction of circadian rhythm was highly associated with hyperactivation of the Wnt signaling pathway in human disease cases (e.g., autism spectrum disorder, colorectal cancer, and osteoarthritis) [50,51,52], suggesting a higher risk of disease gene expression in the dark according to the phase distribution of WNT2B gene expression (peak at 20:00) in the current study. This evidence concerns the gene WNT2B and colorectal cancer.