A study utilizing aptamer-based proteomics in a comparison between AD, frontotemporal dementia (FTD) and controls showed that six proteins, fibronectin (FN), FN1.3, FN1.4, von Willebrand factor (VWF) and extracellular matrix protein 1 (ECM1), were discriminatory with elevation in AD in comparison with both FTD and controls [23]. This evidence concerns the gene TNFRSF12A and Alzheimer disease.