Here, we report changes in Alzheimer-related plasma proteins in women with PCOS in comparison with women without PCOS, and intriguingly, the pattern of protein changes, with higher APP and lower SNCA, that was seen in this PCOS cohort was reflected in the basal samples of a cohort of subjects with T2D using the same aptamer-based technology, and those, in turn, reflected findings reported for AD [40,41,42]. This evidence concerns the gene SNCA and type 2 diabetes mellitus.