For the four proteins that differed between PCOS subjects and control women (APP, APCS, ApoE and SNCA), correlations with age; BMI; insulin resistance (HOMA-IR); testosterone; circulating levels of selected inflammatory proteins and protective heat shock proteins (HSPs); interleukin 6 (IL6); tumor necrosis factor alpha (TNFa); HSP90AA1 (termed heat shock protein 90; HSP90); and HSPD1 (termed heat shock protein 60; HSP60)) were performed. The gene discussed is SNCA; the disease is Insulin resistance.