These findings are, therefore, important given a report showing AD-related proteins in T2D and the relationship of T2D with AD, and the findings here for the same AD-related proteins in PCOS are supported by an aptamer-based proteomic study that showed discriminatory differences in six proteins in AD (FN, FN1.3, FN1.4, VWF and ECM1) that were elevated in AD in comparison with both FTD and controls [23]; here, all but ECM1 were elevated in PCOS in comparison with controls. Here, ECM1 is linked to type 2 diabetes mellitus.