A comparison between APP, APCS, SNCA and ApoE in T2D showed that the proteins APP and APCS in PCOS mirrored the same changes seen in a T2D cohort [24], and indeed, a comparison between the PCOS and T2D plasma values showed comparable levels, though SNCA was significantly higher in PCOS (p < 0.01)(Table 3). This evidence concerns the gene SNCA and type 2 diabetes mellitus.